2018
4/10/2018: Congratulation to Feifei Zhang for that her paper entitled “Hepatic CREBZF Couples Insulin to Lipogenesis by Inhibiting Insig activity and Contributes to Hepatic Steatosis in Diet-Induced Insulin-Resistant Mice” published at Hepatology. The manuscript was submitted on 24 January 2018, resubmitted on 20 March 2018, and finally accepted for publication on 5 April 2018. In the study, Feifei Zhang and her colleagues identified CREB/ATF bZIP transcription factor (CREBZF) of the activating transcription factor/cAMP response element-binding protein (ATF/CREB) gene family as a key regulator for lipogenesis through insulin-Akt signaling. These findings uncover an unexpected mechanism that couples changes in extracellular hormonal signals to hepatic lipid homeostasis; disrupting CREBZF function may have the therapeutic potential for treating fatty liver disease and insulin resistance.
4/19/2018: Congratulation to Yaqian Xue for passing the PhD Qualifying Exam
5/10/2018: Congratulation to PhD degree graduation for Feifei Zhang
5/12/2018: Li Lab organized a tour named “续力2018” on Shengsi island (嵊泗), Zhoushan, Zhejiang
5/19/2018: Li Lab took part in “Public Science Day” held by Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences (SINH, CAS) and Chinese Society of Biochemistry and Molecular Biology (CSBMB).
7/3/2018: Dr. Wen-Xing Ding from the Department of Pharmacology, Toxicology and Therapeutics, the University of Kansas Medical Center, Kansas City, USA to give a talk entitled “Autophagy in Drug-Induced Liver Injury and Tumorigenesis: Friend or Foe?” hosted by Dr. Yu Li at Shanghai Institute of Nutrition and Health, SIBS, CAS, Shanghai.
8/24/2018: Dr. Yu Li was invited to give a talk entitled “Nutrient Sensing and Metabolism Regulation in the Liver” at the 17th Annual Meeting of Chinese Society of Endocrinology (CSE), Hangzhou International Expo Center, Zhejiang.
10/18/2018: Dr. Yu Li was invited to give a talk entitled “Nutrient Sensing and Metabolism Regulation” at the Nutrition, Energy Metabolism and Obesity Conference, School of Public Health of Tongji Medical College, Huazhong University of Science and Technology, Wuhan.
11/5/2018: Dr. Yu Li was invited to give a talk entitled “Molecular Control of Hepatic De Novo Lipogenesis and NAFLD” at the 1st meeting of Chinese Association of Pathophysiology affiliated Endocrinology and Metabolism Committee, Tianjin Medical University, Tianjin.
11/14/2018: Congratulation to Dr. Yunzhi Yang and Fengguang Ma for that their paper entitled “The ER-localized Ca2+-binding protein calreticulin couples ER stress to autophagy by associating with microtubule-associated protein 1A/1B light chain 3” published at Journal of Biological Chemistry. The study discovered that a quality-control ER chaperon, Calreticulin, is induced under ER stress and triggers autophagy via interacting with MAP1LC3 (LC3). This axis promotes the degradation of aberrantly folded proteins and alleviation of ER stress via a negative feedback loop, which may provide potential therapeutic strategies for hyperactive ER stress and its related disorders.
11/15/2018: Congratulation to PhD degree graduation for Yamei Han.
11/29/2018: The Li lab attended the Chinese Diabetes Association (CDS)’s 22th scientific meeting in Suzhou.
12/3/2018: Dr. Bin Gao from NIH/NIAAA, USA to give a talk entitled “Interleukin-22 (IL-22): a magic potion for epithelial repair from bench to bedside” hosted by Dr. Yu Li at Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai.
12/21/2018: Join the Li lab’s Christmas house party with gift exchanges for friends and colleagues, where fun will be had and memories will be made. Work on your research projects as fun as opening your festive Christmas gift. Goodbye 2018, welcome the New Year of 2019.
12/25/2018: Genxiang Cai and Weitong Su Joined the lab as PhD graduate students.
